再摂食症候群はどのようにしてピット水腫を引き起こしますか?


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How do you feed a starving person in a way that won't kill them?」の回答では、リフィーディング症候群は末梢性浮腫を引き起こす可能性があると述べられています。これはどのように起こりますか?

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During refeeding syndrome (RFS), intake of carbohydrates causes a massive surge in insulin levels, leading to electrolyte abnormalities. Increased insulin also caused sodium and water retention independent to changes of renal GFR and RPF [1]. Water retention increases capillary hydrostatic pressure, leading to peripheral edema.

Another possible contributor to peripheral edema during RFS is hypoalbuminemia, which decreases capillary oncotic pressure [2].

Sources:

  1. "The Effect of Insulin on Renal Sodium Metabolism". R.A. DeFronzo
  2. "Refeeding syndrome". J. Fuentebella, J.A. Kerner